Dr. Jianping Xu has established several animal model of cardiovascular disease, such as rodent heart transplantation, myocardial infarction, hypertension under sophisticated microsurgery techniques with his intensive research background both in clinic and basic studies.

 

Our recent research results indicated that cigarette smoking exposure to the recipients' results in severe allograft rejection and accerated graft loss via rat heart transplantation and smoking model.  These data provided new information that either donor alone or both the recipients and donors are equally critical for the survival of organ transplantation. Such adverse effects of cigarette smoke exposure will allow the development of ameliorating strategies to prolong allografts survival.

1. Molecular laboratory skills: Polymerase chain reaction using sequence specific primers (PCR-SSP), Real-Time PCR, Genotyping technique, Free radical oxygen, lipid peroxide analysis, radioimmunoassay, Masson Trichrome Staining for heart histological examination. Genetic prenatal diagnosis of the isolation of fetal cell from the peripheral blood of the pregnant women.

2. Small animal diseases remodeling, microsurgery techniques: Rat and mice heart infarction modeling via surgical procedure by general anesthesia and treatment; Rat and mice heart transplantation surgery; Rat and mice mini-osmotic pump implantation surgery for hypertension remodeling; Rat and mice Langendorff heart perfusion; Rat and mice diabetes remodeling

3. Medical Imaging analysis: Rat and mice echocardiography; Rat and mice MRI imaging collection and analysis

4. 3D/4D clinical ultrasound
A. Static surface rendering reconstructing fetal surface structure image.
B. Static maximum value translucent rendering detecting fetal skeleton structure and formation.
C. Dynamic color and power Doppler rendering for maternal-fetal circulation reconstruction.
D. Birth defects evaluation and prenatal diagnosis.

5. Color Doppler ultrasound
A. Color Doppler ultrasound detecting uterine-placental circulation in normal and high risk pregnancy
B. Fetal umbilical cord nuchal entanglement, placental abnormalities, intrauterine growth restriction.

6. Ultrasound guidance clinical diagnosis and treatment of Obstetrics and Gynecology: Human chorionic villi sampling (CVS), amniocentesis, percutaneous umbilical blood Sampling (PUBs), biophysical profiles with fetal echocardiography, hysterosalpingography, ectopic pregnancy treatment by methotrexate.

7. Ultrasound of reproductive medicine: Endometrial thickness monitoring, follicular tracking, IVF-ET, multifetal pregnancy reduction and selective termination guided by ultrasound.

2007 March - Present: University of Maryland, Department of Medicine
2004 November - March 2007: Case Western Reserve University, Department of Biomedical Engineering
2004 August - October 2004: Washington University in St. Louis, Department of Medicine
1999 February - July 2004: Tongji Medical College, Huazhong University of Science and Technology, Depart of OB/GYN
1998 February - January 1999: St. George's Hospital Medical School, University of London, Department of Obstetrics and Gynecology, Medical Physics and Bioengineering, UK
1986 July - January 1998: Tongji Medical University, Department of Obstetrics and Gynecology

Adverse effects of nicotine and immunosuppression on proximal tubular epithelial cell viability, tissue repair and oxidative stress gene expression. J heart Lung Transplant 2009 (in press)

 

pre-transplant donot or recipient tobacco smoke exposure accelerates cardiac allograft rejection, vasculopathy and graft loss. Final revision. Circulation