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The UMB Postdoctoral Network
 
 
 









Joseph Ryan Mauban
Graduate of UMB, Department of Physiology, 2003

jmauban@umaryland.edu

Mentor: Dr. Meredith Bond
Department of Physiology

Research

Previous studies in animal models of hypertension have shown that arterial contractility can be increased in hypertensive animals.  This change implicated the Rho/Rho kinase signaling pathway.  The current research project focuses on the mechanism/s involved in the increase in contractility and the putative central role of the rho/rho kinase signaling pathway in the pathological process.  We employ multiple techniques that include molecular biology, protein chemistry, widefield and confocal microscopy for our experiments.

Research Techniques

Personal History

EDUCATION
  • 2003 PhD Physiology, University of Maryland, Baltimore
  • 1997 MS Physiology, University of Maryland, Baltimore
  • 1996 BA Cornell University (Neurobiology and Behavior)
 
EMPLOYMENT
  • 1997-1998 Research Assistant, Physiology Department, University of Maryland, Baltimore
  • 04/’04-8/’05 Post Graduate Research scientist, UCSD La Jolla CADept of Medicine, UCSD School of Medicine
  • 10/05-05/06   Postdoctoral Fellow Johns Hopkins University School of Medicine, Dept of Medicine, Division of Pulmonary & Critical Care
  • 06/06-present Postdoctoral Fellow University of Md School of Medicine, Dept of Physiology

Publications

Primary Published Work
 
  1. Miriel V, Mauban J, Blaustein M, Wier WG.  Local and cellular Ca2+  transients in smooth muscle of pressurized rat resistance arteries during myogenic and agonist stimulation.  J Phys 518.3:815-824 (1999).
  2. Wier WG, Balke CW, Michael J, Mauban J.  A Custom confocal and two-photon digital Laser scanning microscope.  Am J Phys Heart Circ Phys 278: H2150-H2156 (2000).
  3. Izu L, Mauban J, Balke CW, Wier WG.  Large Currents Generate Cardiac Ca2+ Sparks.  Biophys J vol 80 Jan:88-102 (2001).
  4. Mauban J, Lamont C, Balke CW, Wier WG.  Adrenergic stimulation of rat resistance arteries affects Ca2+ sparks, Ca2+ waves, and Ca2+ oscillations.  Am J Phys Heart Circ Phys 280: H2399-H2405 (2001).
  5. Mauban J, Wier WG.  Essential role of EDHF in the initiation and maintenance of vasomotion in rat mesenteric arteries.  Am J Phys Heart Circ Phys 287: H608-H616 (2004).
  6. Mauban JR, Remillard CV, Yuan JX.  Hypoxic pulmonary vasoconstriction: role of ion channels.  J Appl Physiol. 2005 Jan;98(1):415-20.
  7. Mauban JR, Wilkinson K, Schach C, Yuan JXJ.  Histamine-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells.  Am J Physiol Cell Physiol. 2006 Feb;290(2):C325-36.

Published Abstracts

  1. Wier WG, Mauban J, Miriel V, Blaustein M.  Calcium Sparks in Smooth Muscle Cells of Pressurized arteries.  Biophys J vol 76:1, pg A291 (1999).
  2. Mauban J, Lamont C, Zang WJ, Wier WG.  Calcium signaling during adrenergic vasoconstriction and  vasomotion of isobaric rat mesenteric arteries.  7th ISRA Ontario Canada, pg 23 (2001).
  3. Mauban J, Wier WG.  Essential role of EDHF in the initiation and maintenance of vasomotion in rat mesenteric arteries.  FASEB SRC Smooth Muscle, abstract #35 (2003).
  4. Mauban JRH, Wilkinson K, Yuan J X.-J.  Activation of SOC in human PAEC without complete depletion of Ca2+ stores.  [Meeting] FASEB 2005.

 

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