| Research
My general interests are in understanding the neurobiological basis for cognitive, social, and emotional processing. I am particularly interested in how alterations in brain connectivity and function develop into the types of behavioral disturbances that characterize certain psychiatric disorders such as schizophrenia, depression, and autism. I am also intrigued by sex differences in these brain functions and behavioral disturbances . My current projects investigate the sex-dependent effects of neonatal exposure to cannabinoids on the developing amygdala in both male and female rat pups.
Research Techniques
Systemic and intracranial drug infusions; sterotaxic surgery; permanent and reversible lesions; in vivo brain microdialysis; western blots; immunohistochemistry; blood glucose monitoring/ glucose tolerance; high performance liquid chromatography; spectrophotometry; ELIZA; behavioral measures of learning, memory, and/or stress/anxiety (e.g., spontaneous alternation, inhibitory avoidance, elevated plus maze, conditioned defeat); international affective pictures system (IAPS); fMRI
Personal History
I graduated from Virginia Tech in 2001 with a B.S. in Psychology and minors in Biology and Chemistry. I then attended Georgia State University for 5 years where I received a M.A. and Ph.D. in Psychology with a concentration in neuropsychology and behavioral neuroscience in 2006. I am currently a postdoctoral fellow at the University of Maryland, Baltimore School of Medicine.
Publications
Journals
Krebs-Kraft, D. L., Rauw, G., Baker, G.B., & Parent, M.B. (2009). Zero net flux estimates of septal extracellular glucose levels and the effects of glucose on septal extracellular GABA levels. European Journal of Pharmacology, 611(1-3):44-52.
Cisse, R.S., Krebs-Kraft, D.L., & Parent, M.B. (2008). Septal infusions of the HCN-channel blocker ZD7288 impair spontaneous alternation but not inhibitory avoidance. Behavioral Neuroscience 122(3), 549-556.
Krebs-Kraft, D.L., & Parent, M. B. (2008). The effects of glucose on memory are brain region-dependent. Neurobiology of Learning and Memory, 89(2), 142-152.
Krebs-Kraft, D. L, Wheeler, M. G., & Parent, M. B. (2007). Hippocampal infusions of bicuculline block the memory-impairing effects of septal GABA receptor activation. Learning and Memory, 14(12), 833-841.
Krebs-Kraft, D. L., Frantz, K. J., & Parent, M. B. In vivo microdialysis: A method for sampling extracellular fluid in discrete brain regions. Handbook of Neurochemistry and Molecular Neurobiology, 3rd Edition Practical Neurochemistry Methods. Baker, G., Dunn, S. and Holt, A., editors.(2007). Springer, New York, NY.
Gore, J., Krebs, D. L., & Parent, M. B. (2006). Changes in blood glucose and salivary cortisol are not necessary for arousal to enhance memory in young or older adults. Psychoneuroendocrinology, 31, 589-600.
Krebs, D. L., & Parent, M. B. (2005). Hippocampal infusions of the glycolytic metabolite pyruvate reverse the memory-impairing effects of septal GABA receptor activation. European Journal of Pharmacology, 520 (1-3), 91-99.
Krebs, D. L., & Parent, M. B. (2005). The enhancing effects of hippocampal infusions of glucose are not restricted to spatial working memory. Neurobiology of Learning and Memory,83,168-172.
Consenzo, K., Franchina, J.J., Eisler, & Krebs, D. (2004). Effects of masculine gender relevant task instructions on men’s cardiovascular reactivity and mental arithmetic performance. Psychology of Men and Masculinity, 5(2), 103-111.
Abstracts
Krebs-Kraft, D.L., Hill, M.N., Hillard, C. J. & McCarthy, M.M. (2009). Cannabinoids mediate a sex difference in cell genesis in the developing medial amygdala. Society for Neuroscience Abstracts, Chicago, IL.
Krebs-Kraft, D.L.., & McCarthy, (2009). Cannabinoids mediate a sex difference in cell genesis in the developing medial amygdala. Gordon Research Conference: Cannabinoid Function in the CNS, Biddeford, ME.
Krebs-Kraft, D.L. & McCarthy, M.M. (2009). Cannabinoids mediate a sex difference in cell genesis in the developing medial amygdala. Early Life Programming and Neurodevelopmental Disorders, Philadelphia, PA.
Krebs-Kraft, D.L. & McCarthy, M.M. (2009). Cannabinoids mediate a sex difference in cell genesis in the developing medial amygdala. Organization for the Study of Sex Differences. Toronto, ON.
McCarthy, M.M.. Zhang, J-M., Krebs-Kraft, D.L., Waddell, J. and Bowers, J.M. (2009). A novel source of sexual dimorphism in the mammalian brain: steroid induced cell genesis. 5th International Meeting on Steroids and Nervous System, Torino, Italy.
Krebs-Kraft, D. L. & McCarthy, M.M. (2008). The cannabinoid agonist, WIN 55,212-2, decreases the number of new cells that express GFAP in the developing medial amygdala of female rats. Society for Neuroscience Abstracts, Washington, D.C.
Dean, S.L., Krebs-Kraft, D.L., & McCarthy, M.M. (2008). Prostaglandins and estradiol reduce dendritic spine number in the cerebellum during the second week of postnatal development. Society for Neuroscience Abstracts, Washington, D.C.
Krebs-Kraft, D.L., & McCarthy, M.M. (2008). Estradiol increases the number of new cells that express GFAP in the developing amygdala. Organization for the Study of Sex Differences, Washington, D.C.
Dean, S., Krebs-Kraft, D.L. & McCarthy, M.M. (2007). Nimesulide, a cox-2 inhibitor, changes the expression of synaptic proteins in the developing cerebellum. Society for Neuroscience Abstracts, San Diego, CA.
Krebs-Kraft, D.L., Zupp, S.L., Cardarelli, R.A., & McCarthy, M.M. (2007). Sex differences in the detection of new cells in the developing amygdala. Society of Neuroscience Abstracts, San Diego, CA.
Dean, S., Krebs-Kraft, D.L. & McCarthy, M.M. (2007). Effects of the cox-2 inhibitor nimesulide on cerebellar synaptic protein expression. Society for Behavioral Neuroendocrinology Abstracts, Asimolar, CA.
Krebs-Kraft, D.L. & Parent, M.B. (2006). Septal co-infusions of muscimol with scopolamine produce spontaneous alternation and avoidance retention deficits. Society of Neuroscience Abstracts, Atlanta, GA.
Cisse, R. S., & Krebs-Kraft, D. L., & Parent, M.B. (2006). Septal infusions of the H-channel blocker ZD7288 impairs memory in a task-dependent manner. Society of Neuroscience Abstracts, Atlanta, GA
Lin, S.M., Krebs-Kraft, D.L., & Huhman, K.L. (2006). Temporary inactivation of the anterior dorsal hippocampus does not alter behavioral effects of social defeat in male Syrian hamsters. Society of Neuroscience Abstracts, Atlanta, GA
Parent, M. B., Cisse, R. S., & Krebs, D. L. (2006). Septal infusions of the H-channel blocker ZD7288 impair spontaneous alternation in male rats. Eighth Conference on the Neurobiology of Learning and Memory, Irvine, CA.
Krebs, D. L., Solomon, M. B., Parent, M. B., & Huhman, K. L. (2005). Post-defeat injection of the beta adrenergic antagonist propranolol impairs the formation of conditioned defeat in syrian hamsters. 2005 Workshop on the Neuroendocrinology of Stress, San Diego, CA.
Krebs, D. L., Parent, M. B. (2005). Hippocampal infusions of glucose reverse the memory-impairing effects of co-infusions of a GABA receptor agonist. Society of Neuroscience Abstracts, Washington, DC.
Ryan, J.P., Krebs, D. L., Nolan, C.L, Tessner, K.D., Hamann, S.B., & Parent, M. B. (2005). Blood glucose levels correlate with medial temporal lobe and prefrontal brain activation during encoding for words. Society of Neuroscience Abstracts, Washingtion, D.C.
Krebs, D. L. & Parent, M. B. (2004). Septal co-infusions of glucose and the benzodiazepine chlordiazepoxide impair spontaneous alternation. Society for Neuroscience Abstracts, San Diego, CA.
Parent, M. B. & Krebs, D. L. (2004). The memory enhancing effects of hippocampal glucose infusions override the impairing effects of septal glucose infusions. Winter Conference on the Neurobiology of Learning and Memory, Park City, Utah.
Krebs, D. L., & Parent, M. B. (2004). Hippocampal infusions of bicuculline reverse spontaneous alternation deficits produced by septal GABA receptor activation: Implications for septo-hippocampal interactions. Winter Conference on the Neurobiology of Learning and Memory, Park City, Utah.
Krebs, D. L., & Parent, M.B. (2003). Hippocampal infusions of pyruvate reverse avoidance deficits produced by septal GABA receptor activation. Society for Neuroscience Abstracts, New Orleans, LA.
Krebs, D. L., Board, E.M. & Parent, M.B. (2002). Hippocampal infusions of glucose and pyruvate reverse the spontaneous alternation deficits produced by septal infusions of the GABA receptor agonist muscimol. Society for Neuroscience Abstracts, Orlando, FL.
|